After the player receives a pop-up message regarding the decision to aggressively target ape populations, drones will begin to appear on the map.
Once a drone has spawned, it will fly over ape colonies and begin to kill the apes there within its targeting radius.
The player has no way to prevent drones from attacking, and must make the apes travel out of the drones attack area to save their apes.
Drones' area will flashing red a few seconds before attacking. If a colony exists within a drone's radius when they attack, the colony is destroyed. Apes present in a country without a colony are not harmed.
If a drone is attacking when a group of traveling apes are in the drone's radius, the traveling apes are killed.
In the Shadow Plague, drones are used by the Templars to eliminate Vampire Lairs, thus weakening the vampires in the country. However, unlike in the Simian Flu, Vampires can actively attack and destroy drones in order to protect their lairs.
- There are two achievements involving drones: Attack of the drones, which involves allowing a Colony to be destroyed by a drone attack, and EvacuApe, which involves moving a Colony out of the attack zone of a drone.