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The Kill Switch is the switch on the Nano-Virus which makes it lethal. It is supposedly extremely dangerous, and scientists worldwide are determined to destroy and deactivate it, presumably rendering it innocuous or possibly beneficial to mankind. This attempt to deactivate the Kill Switch begins as soon as the game starts, which is what makes the Nano-Virus one of the fastest-paced plagues in the game. You have 7 exclusive upgrades that hack the cure and resist it.