Mirror Earth is a scenario in which the player "steps through the mirror into the land of opposites where hot becomes cold and cold becomes hot, rich becomes poor and... You get the idea!"
In this scenario, countries that would otherwise have a cold climate now have a hot climate, and the opposite applies for countries that have a hot climate. Similarly, rural regions become urban, and urban regions become rural. Humidity becomes aridity, and aridity becomes humidity. Poverty becomes wealthy, and the opposite happens elsewhere in the world. Some things, however, do not differ from the classic scenario. For example, Russia and Greenland are still the most sparsely populated countries in the world. Additionally, most of the rich, urban, and cold countries in this scenario are in Africa, so players may notice that cure research is slightly higher than normal. This is because there are 356 bottles instead of 340 because their are more rich, urban, and cold countries than normal. Finally, the amount of research facilities in each country changes (Unless said Country has 6 facilities in the base game). The countries with the most Research Facilities in the standard game will have the least amount in Mirror Earth, and countries that typically have the least Research Facilities will have the most in this scenario. Below is a table that shows the specific change in Research Facilities:
|Facilities in standard game||Facilities in Mirror Earth|
|Scenarios in Plague Inc. and Plague Inc: Evolved.|
| Artificial Organs ● Black Death ● Created Equal ● Frozen Virus ● Global Warming ● Golden Age ● Ice Age ● Mirror Earth ● Nipah Virus ● Pirate Plague ● Santa's Little Helper ● Shut Down Everything ● Smallpox ● Sovereign Default ● Swine Flu ● Teleportation ● Unknown Origin ● Volcanic Ash ● Who Cares ● Xenophobia|