This page is for strategies for the Smallpox scenario. Feel free to add your own strategies, tips, and Q&A below:

Strategies (by Risviltsov)Edit

Risviltsov here! Sorry for the four-week absence, I was busy on Tanki Online and other stuff such as winter preparations. I'm back, though, and here's a highly requested guide that I'll release to you here. Let's get right to it! This guide is divided into four sections, each for the four difficulties.

Casual Smallpox Edit

Here's what you need to perform to complete Smallpox on Casual difficulty.

Genetic Code Edit

  • ATP Boost
  • Genetic Mimic
  • Aquacyte
  • Extremophile
  • Sympto-Stasis

Phase I - Hide! Edit

Start in Saudi Arabia! Unfortunately, Smallpox has a very high starting severity and lethality, but this can be fixed! Devolve the following symptoms, I've prioritized them into which ones to devolve first.

  1. Pustules
  2. Systemic Infection
  3. Pneumonia
  4. Fever

Unfortunately, these aren't enough to be able to hide away from 100,000 infected alone. You'll also need to evolve White Pox 1.

Phase II - Infect! Edit

You'll need to be able to infect everyone, so evolve some of these transmissions.

  • Droplets II
  • Droplets III
  • Fomities I
  • Air I
  • Air II
  • Water I
  • Water II
  • Fomities II
  • Extreme Bioaerosol

Phase III - Resist! Edit

Your strain is very weak! (as weak as the Necroa Virus, having $9 million to defeat you) Let's make it stronger! (Evolve most of the following abilites)

  • Cold Resistance I
  • Cold Resistance II
  • Drug Resistance I
  • Vaccine Shield
  • Genetic Hardening I
  • Genetic Hardening II
  • Drug Resistance II

Phase IV - Massacre! Edit

Once the Caribbean and Greenland has been infected, we'll need to rapidly eradicate the human population. Evolve the following, prioritized for your convenience.

  1. Systemic Infection > Necrosis > Black Pox > Haemorrhagic Shock > Internal Haemorrhaging > Total Organ Failure with Fever > Coma
  2. Systemic Infection > Necrosis > Osteomyelitis, Immune Suppression, Fever > Acute Encephalitis - Coma > Dysentery > Diarrhoea
  3. Black Pox > Haemoptysis > Purpura > Internal Haemorrhaging > Total Organ Failure - Haemorrhagic Shock and Systemic Infection

Normal Smallpox Edit

Smallpox is only a tad more difficult when you raise the difficulty up from Casual to Normal. Here's what you need to beat it on Normal.

NOTE: Devolve any mutations unless otherwise stated.

Genetic Code Edit

  • ATP Boost
  • Genetic Mimic
  • Aquacyte
  • Extremophile
  • Translesion +

Phase I - Hide, once again! Edit

Start in Saudi Arabia.

We still need to hide our little strain of Variola Major. The emphasis here is that we need to do it more effectively. Devolve these symptoms immediately.

  • Pustules
  • Systemic Infection
  • Pneumonia

We need to focus on nullifying the severity and the lethality. Continue playing and do the following.

  1. Devolve Fever.
  2. Evolve White Pox 1.
  3. Evolve White Pox 2.

By now, the severity and the lethality should be at zero. Now we shall infect!

NOTE: If anything mutates and there is still no lethality or severity, leave it be. It will help us during our murderous attack at the end of this guide.

Phase II - Infect them all! Edit

To be honest, we don't need to evolve anything, but if we don't want to lose a lot of DNA due to devolving mutations, we should at least evolve something that helps spread our disease. Evolve the following transmissions.

  • Droplets 2
  • Droplets 3

This should be enough to use planes as our primary transmission vector. We also need to fight back the soon to occur cure and we need to raise infectiousness in cold climates, so evolve the following abilities.

  • Drug Resistance 1
  • Cold Resistance 1
  • Genetic Hardening 1
  • Genetic Hardening 2
  • Cold Resistance 2

Phase III - MURDER! Edit

Once everyone in the world is infected, you must start killing everyone off. To start, devolve the following.

  • White Pox 2
  • White Pox 1

Now, if you can, evolve the following.

  • Black Pox
  • Immune Suppression

If you are lucky, they will not figure out your plague until 100 million people have died. This is what happened with me, but this guide still works even if that is not the case. Evolve the following to bring doom onto the world that has treated you like you were dirt!

  • Anything that increases lethality, such as Systemic Infection
  • Anything that slows down cure efforts, such as Corneal Ulceration
  • If at any point the cure is at an uncomfortable progress, evolve Genetic ReShuffles or evolve something that slows down cure efforts.

Here is what my results were:

  • Score Total: 29,312
  • Time: 747 days
  • Cure: 72% complete

Strategies (by Troubledsoul25) Edit

Instead of going 'sneaky-beaky' like most people would think, I choose more aggressive approach on this disease, exploiting its high initial infectivity and lethality. Tested on both Normal and Brutal difficulty with 2 biohazards guaranteed.

Genes required Edit

How to play Edit

  1. Start in India.
  2. Evolve Droplets 2 and 3.
  3. After you infected few people, they may already notice the disease, but don't worry, this was expected.
  4. Evolve Vaccine Shield as soon as they start vaccination programme. Pay attention to the news or infected count. If it is decreasing then the vaccination program is already begun.
  5. Evolve Drug Resistance 1, Genetic Hardening 1 and2, and Cold Resistance 1.
  6. Evolve Fomites 1, Water 1 and2, Heat Resistance 1 and 2, and Environmental bring the plague worldwide faster.
  7. At this point, you might want to slow down the time, as the plague spread to countries really fast you might miss some of those red bubbles.
  8. Evolve Necrosis, Corneal Ulceration, Coma, and the remaining vaccine shields. Don't worry about your plague killing faster than infecting. Its infection rate is always faster than its death rate.
  9. Evolve Fomites 2, Air 1 and 2, Extreme Bioaerosol, and Cold Resistance 2.
  10. Evolve some symptoms to increase the lethality.
  11. If the cure progress is worryingly high, evolve Genetic Reshuffles.
  12. When every country in the world is infected, then that's it, you won!

Here are my results :

Normal :

  • Score Total : 55,197
  • Time : 387 days
  • Cure progress : 80% complete

Brutal :

  • Score Total : 52,914
  • Time : 390 days
  • Cure progress : 90% complete
Strategy guides in Plague Inc. and Plague Inc: Evolved.
Speed Run/Bio-WeaponSpeed Run/PrionSpeed Run/Shadow PlagueStrategy Guide/Complete Mirror EarthStrategy guide/Film FanaticStrategy guide/Golden AgeStrategy guide/Not Just a Pretty FaceStrategy guide/Pirate PlagueStrategy Guide/Shadow PlagueStrategy guide/Shut Down EverythingStrategy guide/Volcanic AshStrategy Guide/Watery GraveStrategy guide/XenophobiaStrategy Guides/An Ape is for Life...Strategy Guides/BacteriaStrategy Guides/Banana SkinStrategy Guides/Big BangStrategy Guides/Bio-WeaponStrategy Guides/Black DeathStrategy Guides/Breathe DeepStrategy Guides/Chinese Nuclear RetaliationStrategy Guides/ChiroptophobiaStrategy Guides/Dead EndStrategy Guides/Don't Ask MeStrategy Guides/Due DiligenceStrategy Guides/Frozen VirusStrategy Guides/FungusStrategy Guides/Getting ColderStrategy Guides/Hide and SeekStrategy Guides/I am your FatherStrategy Guides/I never asked for thisStrategy Guides/Insane BoltStrategy Guides/It's a Trap!Strategy Guides/Mad Cow DiseaseStrategy Guides/Making AmendsStrategy Guides/Nano-VirusStrategy Guides/Necroa VirusStrategy Guides/Neurax WormStrategy Guides/No IdeaStrategy Guides/Non StarterStrategy Guides/Not Another Zombie GameStrategy Guides/ParasiteStrategy Guides/Patient Who?Strategy Guides/Peer PressureStrategy Guides/Plague in SpaceStrategy Guides/PrionStrategy Guides/Pus ExplosionStrategy Guides/Revenge of OsirisStrategy Guides/Russian Nuclear RetaliationStrategy Guides/SadomasochistStrategy Guides/Santa's Little HelperStrategy Guides/Shadow PlagueStrategy Guides/Shouldn't Keep PetsStrategy Guides/Simian FluStrategy Guides/Simian Flu Gene FarmingStrategy Guides/SmallpoxStrategy Guides/Starting CountryStrategy Guides/TeleportationStrategy Guides/Test This!Strategy Guides/VirusStrategy Guides/Who CaresStrategy Guides/Who needs brainsStrategy Guides/Who needs DEETStrategy Guides/Wolf Pack
Strategy guide

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.