Plague Inc. Wiki


981pages on
this wiki
Add New Page
Comments69 Share

Symptoms can be evolved through the Symptoms screen. Evolving a symptom costs DNA points, but each evolution will make your pathogen increasingly deadly, infectious or frightening.

In the standard diseases, there are 6 symptoms available immediately. The others must be evolved after you have evolved a symptom in contact with it. These initially available symptoms are: Nausea, Coughing, Rash, Insomnia, Cysts, and Anaemia. The most deadly are Hemorrhagic Shock, Total Organ Failure, and Necrosis.

Certain symptoms will create Symptom Combos, which generally increase disease effectiveness, but also increase awareness of the disease. Some combos increase research speed while others decrease it. They are not reversible; once they evolve they remain in effect even if you devolve the symptoms that triggered them.

The below table lists base symptom costs for each symptom. These do not remain static unless you have enabled the Sympto-Stasis Gene. Otherwise, the first symptom that you evolve from the six initially available will have the value listed; each symptom evolved after that will have an additional point added - cumulatively. For example, going up the tree from Cysts to Total Organ Failure progresses as follows: Cysts for 2 points, Hyper-Sensitivity 3 points, Paralysis 12 points, Coma 24 points, and Total Organ Failure 35 points. Since you would never do just those symptoms, and Total Organ Failure is usually close to being the final symptom you evolve, it can easily cost you 45 points or more for that single trait. This is something that needs to be kept in mind when planning your strategy during play and your DNA budgeted accordingly.

Name Effect Base Cost
Nausea Irritated stomach lining leads to discomfort. Slight chance of infection when kissing 2 DNA
Coughing Chance of infection by spreading pathogen into surroundings, especially in high density, urban areas 4 DNA
Rash The skin becomes blistered and painful, slightly increasing infectivity 3 DNA
Insomnia Inability to sleep makes people irritable and less productive 2 DNA
Cysts Painful lumps containing pockets of the pathogen. Slight chance of bursting which can spread disease 2 DNA
Anaemia Decrease in red blood cells or haemoglobin in the blood can lead to hypoxia in the organs 2


Vomiting The expulsion of infected material through projectile vomiting increases the risk of infection 4 DNA
Pneumonia Serious fluid build and discharge from the lungs. People in cold climates especially vulnerable 4 DNA
Sneezing Fluid discharge through sneezing greatly increases infection rates. 5 DNA
Sweating The loss of fluid through sweating also increases infection rates due to poor hygiene. More dangerous in cold countries 7 DNA
Paranoia Irrational delusions and mental symptoms. Victims distrust of others makes them unlikely to seek treatment or cooperate with others 5 DNA
Hyper sensitivity Increases likelihood of allergic reactions which can distract the immune system. Rich regions particularly vulnerable 2 DNA
Abscesses Pockets of infected flesh are painful and act as breeding grounds for the pathogen, increasing infection rates when burst 2 DNA
Haemophilia Immune system produces inhibitors that destroy factor VIII, preventing blood clotting. Infectivity increased 8 DNA
Pulmonary Oedema Potentially fatal heart abnormality causes breakdown of respiratory system, releasing pathogen into the air 7 DNA
Fever Increase in temperature, contagiousness and severe dehydration, which can be fatal 9 DNA
Inflammation Inflammation obstructs bodily processes. Swelling can obstruct breathing and be fatal 5 DNA
Tumours Pathogen disrupts cell growth pathways, causing uncontrolled, eventually fatal tumour growth 11 DNA
Diarrhoea Pathogen active in digestive tract, causing infection through faeces and potentially lethal dehydration. Poor countries v. vulnerable. 6 DNA
Pulmonary Fibrosis Scarring of the lungs causes shortness of breath and extreme coughing. Can be fatal when combined with intense exercise. 8 DNA
Immune Suppression Pathogens attach to lymphocytes, suppressing immune system and allowing significantly greater freedom of mutation.Can be fatal. 12 DNA
Skin Lesions Breakdown in the epidermis causes large open wounds which significantly increase infectivity 8 DNA
Seizures Random blackouts and fits reduce the patient's ability to function independently. Can be fatal 4 DNA
Paralysis Pathogen destroys motor neurons to cause paralysis. Significantly harder to cure and can be lethal 10 DNA
Systemic Infection Pathogen affects multiple organ and tissue types, causing body-wide infections that spread fast and can be fatal 17 DNA
Internal Haemorrhaging Arterial membranes break down, causing rapid internal bleeding and death 18 DNA
Dysentery A complete breakdown in the digestive system causes infected sewage, dehydration, starvation and death 19 DNA
Insanity Neuropathic action of the pathogen in the frontal cortex causes severe emotional and behavioural abnormalities. Significantly harder to cure 18 DNA
Necrosis Large swathes of infected tissue lose blood supply and become fatal sources of gangrene. Decomposed bodies remain a vector of transmission 27 DNA
Hemorrhagic Shock Severe loss of blood volume causes oxygen deprivation, loss of consciousness and death 30 DNA
Coma Neuropathic effects in the brain stem cause loss of consciousness and sometimes death. Significantly harder to cure 21 DNA
Total Organ Failure Catastrophic cell death of multiple tissue types causes body-wide organ failure and rapid death 31 DNA

Statistical Page: Edit

Normal Symptoms\Statistical Reference Page [in progress, date TBD]

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.