Stn Total Organ Failure
Total Organ Failure
Total Organ Failure
A patient suffering from total organ failure.


Catastrophic cell death of multiple tissue types causes body-wide organ failure and rapid death

DNA cost



Catastrophic (20)


Catastrophic (25)



Required Symptoms

Immune Suppression or Pulmonary Fibrosis

Total Organ Failure is a Tier 4 symptom. It causes catastrophic cell death of multiple tissue types, which causes body-wide organ failure and rapid death. It increases severity by 20%, and lethality by 25%.


Total Organ Failure is arguably one of the most lethal symptoms in the game and once evolved, it kills rapidly. Even wealthy countries will go down if enough people are infected. However, this extreme lethality increase is a double-edged sword. This symptom can backfire if not handled correctly.

Total Organ Failure should not be evolved before most of the world's population is already infected (for example: 75% of the population, including a fair chunk of Greenland and other hard-to-reach countries). It is commonly used to kill off the world's population rapidly, and is highly recommended to be used at the end of the game to end the game quickly. However, evolving it too early can often result in a game over, as all infected will likely die off before they are able to infect all healthy people.

Interestingly, this symptom loses much of its lethality in the scenario Artificial Organs.

Trivia Edit

This is as lethal as Cytokine storm and Vampiric Awakening, but not as lethal as Total Brain Death or the Unlock Annihilate gene.

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